Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Identifieur interne : 000392 ( Main/Exploration ); précédent : 000391; suivant : 000393Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Auteurs : Brian M. Wolpin [États-Unis] ; Cosmeri Rizzato [Allemagne] ; Peter Kraft [États-Unis] ; Charles Kooperberg [États-Unis] ; Gloria M. Petersen [États-Unis] ; Zhaoming Wang [États-Unis] ; Alan A. Arslan [États-Unis] ; Laura Beane-Freeman [États-Unis] ; Paige M. Bracci [États-Unis] ; Julie Buring [États-Unis] ; Federico Canzian [Allemagne] ; Eric J. Duell [Espagne] ; Steven Gallinger [Canada] ; Graham G. Giles [Australie] ; Gary E. Goodman [États-Unis] ; Phyllis J. Goodman [États-Unis] ; Eric J. Jacobs [États-Unis] ; Aruna Kamineni [États-Unis] ; Alison P. Klein [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Matthew H. Kulke [États-Unis] ; Donghui Li [États-Unis] ; Núria Malats [Espagne] ; Sara H. Olson [États-Unis] ; Harvey A. Risch [États-Unis] ; Howard D. Sesso [États-Unis] ; Kala Visvanathan [États-Unis] ; Emily White [États-Unis] ; Wei Zheng [États-Unis] ; Christian C. Abnet [États-Unis] ; Demetrius Albanes [États-Unis] ; Gabriella Andreotti [États-Unis] ; Melissa A. Austin [États-Unis] ; Richard Barfield [États-Unis] ; Daniela Basso [Italie] ; Sonja I. Berndt [États-Unis] ; Marie-Christine Boutron-Ruault [France] ; Michelle Brotzman [États-Unis] ; Markus W. Büchler [Allemagne] ; H Bas Bueno-De-Mesquita [Pays-Bas] ; Peter Bugert [Allemagne] ; Laurie Burdette [États-Unis] ; Daniele Campa [Allemagne] ; Neil E. Caporaso [États-Unis] ; Gabriele Capurso [Italie] ; Charles Chung [États-Unis] ; Michelle Cotterchio [Canada] ; Eithne Costello [Royaume-Uni] ; Joanne Elena [États-Unis] ; Niccola Funel [Italie] ; J Michael Gaziano [États-Unis] ; Nathalia A. Giese [Allemagne] ; Edward L. Giovannucci [États-Unis] ; Michael Goggins [États-Unis] ; Megan J. Gorman [États-Unis] ; Myron Gross [États-Unis] ; Christopher A. Haiman [États-Unis] ; Manal Hassan [États-Unis] ; Kathy J. Helzlsouer [États-Unis] ; Brian E. Henderson [États-Unis] ; Elizabeth A. Holly [États-Unis] ; Nan Hu [États-Unis] ; David J. Hunter [États-Unis] ; Federico Innocenti [États-Unis] ; Mazda Jenab [France] ; Rudolf Kaaks [Allemagne] ; Timothy J. Key [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Eric A. Klein [États-Unis] ; Manolis Kogevinas [Grèce] ; Vittorio Krogh [Italie] ; Juozas Kupcinskas [Lituanie] ; Robert C. Kurtz [États-Unis] ; Andrea Lacroix [États-Unis] ; Maria T. Landi [États-Unis] ; Stefano Landi [Italie] ; Loic Le Marchand [États-Unis] ; Andrea Mambrini [Italie] ; Satu Mannisto [Finlande] ; Roger L. Milne [Australie] ; Yusuke Nakamura [Japon] ; Ann L. Oberg [États-Unis] ; Kouros Owzar [États-Unis] ; Alpa V. Patel [États-Unis] ; Petra H M. Peeters [Royaume-Uni] ; Ulrike Peters [États-Unis] ; Raffaele Pezzilli [Italie] ; Ada Piepoli [Italie] ; Miquel Porta [Espagne] ; Francisco X. Real [Espagne] ; Elio Riboli [Royaume-Uni] ; Nathaniel Rothman [États-Unis] ; Aldo Scarpa [Italie] ; Xiao-Ou Shu [États-Unis] ; Debra T. Silverman [États-Unis] ; Pavel Soucek [République tchèque] ; Malin Sund [Suède] ; Renata Talar-Wojnarowska [Pologne] ; Philip R. Taylor [États-Unis] ; George E. Theodoropoulos [Grèce] ; Mark Thornquist [États-Unis] ; Anne Tj Nneland [Danemark] ; Geoffrey S. Tobias [États-Unis] ; Dimitrios Trichopoulos [Grèce] ; Pavel Vodicka [République tchèque] ; Jean Wactawski-Wende [États-Unis] ; Nicolas Wentzensen [États-Unis] ; Chen Wu [États-Unis] ; Herbert Yu [États-Unis] ; Kai Yu [États-Unis] ; Anne Zeleniuch-Jacquotte [États-Unis] ; Robert Hoover [États-Unis] ; Patricia Hartge [États-Unis] ; Charles Fuchs [États-Unis] ; Stephen J. Chanock [États-Unis] ; Rachael S. Stolzenberg-Solomon [États-Unis] ; Laufey T. Amundadottir [États-Unis]Source :
- Nature genetics ; 2014.
English descriptors
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Abstract
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
DOI: 10.1038/ng.3052
PubMed: 25086665
Affiliations:
- Allemagne, Australie, Canada, Danemark, Espagne, Finlande, France, Grèce, Italie, Japon, Lituanie, Pays-Bas, Pologne, Royaume-Uni, République tchèque, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Bade-Wurtemberg, Bohême centrale, Californie, Caroline du Nord, Catalogne, Connecticut, District de Karlsruhe, Grand Londres, Géorgie (États-Unis), Hawaï, Hovedstaden, Latium, Maryland, Massachusetts, Minnesota, Ohio, Ontario, Oxfordshire, Tennessee, Texas, Utrecht (province), Washington (État), État de New York
- Barcelone, Cambridge, Copenhague, Heidelberg, Londres, Lyon, Mannheim, Oxford, Prague, Rome, Tokyo, Toronto, Utrecht
- Université Pompeu Fabra, Université autonome de Barcelone, Université d'Oxford, Université de Californie du Sud, Université de Cambridge, Université de Toronto, Université de Washington
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[2] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Rizzato, Cosmeri" sort="Rizzato, Cosmeri" uniqKey="Rizzato C" first="Cosmeri" last="Rizzato">Cosmeri Rizzato</name><affiliation wicri:level="3"><nlm:affiliation>1] Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2].</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. [3].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Petersen, Gloria M" sort="Petersen, Gloria M" uniqKey="Petersen G" first="Gloria M" last="Petersen">Gloria M. Petersen</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Arslan, Alan A" sort="Arslan, Alan A" uniqKey="Arslan A" first="Alan A" last="Arslan">Alan A. Arslan</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA. [2] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [3] New York University Cancer Institute, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA. [2] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [3] New York University Cancer Institute, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Beane Freeman, Laura" sort="Beane Freeman, Laura" uniqKey="Beane Freeman L" first="Laura" last="Beane-Freeman">Laura Beane-Freeman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M" last="Bracci">Paige M. Bracci</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Buring, Julie" sort="Buring, Julie" uniqKey="Buring J" first="Julie" last="Buring">Julie Buring</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="3"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:affiliation>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. [3] Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. [3] Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J" last="Goodman">Phyllis J. Goodman</name><affiliation wicri:level="2"><nlm:affiliation>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J" last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kamineni, Aruna" sort="Kamineni, Aruna" uniqKey="Kamineni A" first="Aruna" last="Kamineni">Aruna Kamineni</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Klein, Alison P" sort="Klein, Alison P" uniqKey="Klein A" first="Alison P" last="Klein">Alison P. Klein</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="2"><nlm:affiliation>The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Kulke, Matthew H" sort="Kulke, Matthew H" uniqKey="Kulke M" first="Matthew H" last="Kulke">Matthew H. Kulke</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Donghui" sort="Li, Donghui" uniqKey="Li D" first="Donghui" last="Li">Donghui Li</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea><wicri:noRegion>Madrid</wicri:noRegion></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H" last="Olson">Sara H. Olson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D" last="Sesso">Howard D. Sesso</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="4"><nlm:affiliation>1] Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C" last="Abnet">Christian C. Abnet</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Austin, Melissa A" sort="Austin, Melissa A" uniqKey="Austin M" first="Melissa A" last="Austin">Melissa A. Austin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Barfield, Richard" sort="Barfield, Richard" uniqKey="Barfield R" first="Richard" last="Barfield">Richard Barfield</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Basso, Daniela" sort="Basso, Daniela" uniqKey="Basso D" first="Daniela" last="Basso">Daniela Basso</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:affiliation>1] INSERM, Centre for Research in Epidemiology and Population Health (CESP), Nutrition, Hormones and Women's Health Team, Villejuif, France. [2] University Paris Sud, UMRS 1018, Villejuif, France. [3] Institut Gustave Roussy (IGR), Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM, Centre for Research in Epidemiology and Population Health (CESP), Nutrition, Hormones and Women's Health Team, Villejuif, France. [2] University Paris Sud, UMRS 1018, Villejuif, France. [3] Institut Gustave Roussy (IGR), Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Brotzman, Michelle" sort="Brotzman, Michelle" uniqKey="Brotzman M" first="Michelle" last="Brotzman">Michelle Brotzman</name><affiliation wicri:level="2"><nlm:affiliation>Westat, Rockville, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Westat, Rockville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W" last="Büchler">Markus W. Büchler</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation wicri:level="3"><nlm:affiliation>1] National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. [2] Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, the Netherlands. [3] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>1] National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. [2] Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, the Netherlands. [3] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, DKFZ, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Capurso, Gabriele" sort="Capurso, Gabriele" uniqKey="Capurso G" first="Gabriele" last="Capurso">Gabriele Capurso</name><affiliation wicri:level="3"><nlm:affiliation>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Chung, Charles" sort="Chung, Charles" uniqKey="Chung C" first="Charles" last="Chung">Charles Chung</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="4"><nlm:affiliation>1] Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. [2] Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. [2] Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Elena, Joanne" sort="Elena, Joanne" uniqKey="Elena J" first="Joanne" last="Elena">Joanne Elena</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Funel, Niccola" sort="Funel, Niccola" uniqKey="Funel N" first="Niccola" last="Funel">Niccola Funel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa</wicri:regionArea><wicri:noRegion>Pisa</wicri:noRegion></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A" last="Giese">Nathalia A. Giese</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Goggins, Michael" sort="Goggins, Michael" uniqKey="Goggins M" first="Michael" last="Goggins">Michael Goggins</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [3] Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [3] Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gorman, Megan J" sort="Gorman, Megan J" uniqKey="Gorman M" first="Megan J" last="Gorman">Megan J. Gorman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gross, Myron" sort="Gross, Myron" uniqKey="Gross M" first="Myron" last="Gross">Myron Gross</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:affiliation>Preventive Medicine, University of Southern California, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preventive Medicine, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hassan, Manal" sort="Hassan, Manal" uniqKey="Hassan M" first="Manal" last="Hassan">Manal Hassan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation wicri:level="2"><nlm:affiliation>Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Prevention, University of Southern California, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A" last="Holly">Elizabeth A. Holly</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hu, Nan" sort="Hu, Nan" uniqKey="Hu N" first="Nan" last="Hu">Nan Hu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard School of Public Health, Boston, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard School of Public Health, Boston, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Innocenti, Federico" sort="Innocenti, Federico" uniqKey="Innocenti F" first="Federico" last="Innocenti">Federico Innocenti</name><affiliation wicri:level="2"><nlm:affiliation>The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, DKFZ, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><nlm:affiliation>School of Clinical Medicine, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Medicine, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Klein, Eric A" sort="Klein, Eric A" uniqKey="Klein E" first="Eric A" last="Klein">Eric A. Klein</name><affiliation wicri:level="2"><nlm:affiliation>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>1] Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [2] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [3] Department of Nutrition, National School of Public Health, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>1] Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [2] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [3] Department of Nutrition, National School of Public Health, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Kupcinskas, Juozas" sort="Kupcinskas, Juozas" uniqKey="Kupcinskas J" first="Juozas" last="Kupcinskas">Juozas Kupcinskas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Kurtz, Robert C" sort="Kurtz, Robert C" uniqKey="Kurtz R" first="Robert C" last="Kurtz">Robert C. Kurtz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T" last="Landi">Maria T. Landi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Landi, Stefano" sort="Landi, Stefano" uniqKey="Landi S" first="Stefano" last="Landi">Stefano Landi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea><wicri:noRegion>Pisa</wicri:noRegion></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Mambrini, Andrea" sort="Mambrini, Andrea" uniqKey="Mambrini A" first="Andrea" last="Mambrini">Andrea Mambrini</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Department, ASL1 Massa Carrara, Massa Carrara</wicri:regionArea><wicri:noRegion>Massa Carrara</wicri:noRegion></affiliation></author><author><name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:affiliation>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation wicri:level="3"><nlm:affiliation>Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L" last="Oberg">Ann L. Oberg</name><affiliation wicri:level="2"><nlm:affiliation>Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Owzar, Kouros" sort="Owzar, Kouros" uniqKey="Owzar K" first="Kouros" last="Owzar">Kouros Owzar</name><affiliation wicri:level="2"><nlm:affiliation>Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V" last="Patel">Alpa V. Patel</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H M" last="Peeters">Petra H M. Peeters</name><affiliation wicri:level="3"><nlm:affiliation>1] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Pezzilli, Raffaele" sort="Pezzilli, Raffaele" uniqKey="Pezzilli R" first="Raffaele" last="Pezzilli">Raffaele Pezzilli</name><affiliation wicri:level="1"><nlm:affiliation>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Piepoli, Ada" sort="Piepoli, Ada" uniqKey="Piepoli A" first="Ada" last="Piepoli">Ada Piepoli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Scientific Institute and Regional General Hospital 'Casa Sollievo della Sofferenza', Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gastroenterology, Scientific Institute and Regional General Hospital 'Casa Sollievo della Sofferenza', Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation wicri:level="4"><nlm:affiliation>1] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [2] Department of Epidemiology, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. [3] CIBERESP, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [2] Department of Epidemiology, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. [3] CIBERESP, Madrid</wicri:regionArea><orgName type="university">Université autonome de Barcelone</orgName><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Real, Francisco X" sort="Real, Francisco X" uniqKey="Real F" first="Francisco X" last="Real">Francisco X. Real</name><affiliation wicri:level="4"><nlm:affiliation>1] Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain. [2] Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1] Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain. [2] Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université Pompeu Fabra</orgName></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name><affiliation wicri:level="1"><nlm:affiliation>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T" last="Silverman">Debra T. Silverman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Soucek, Pavel" sort="Soucek, Pavel" uniqKey="Soucek P" first="Pavel" last="Soucek">Pavel Soucek</name><affiliation wicri:level="3"><nlm:affiliation>Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Perioperative Sciences, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Talar Wojnarowska, Renata" sort="Talar Wojnarowska, Renata" uniqKey="Talar Wojnarowska R" first="Renata" last="Talar-Wojnarowska">Renata Talar-Wojnarowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz</wicri:regionArea><wicri:noRegion>Łodz</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R" last="Taylor">Philip R. Taylor</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Theodoropoulos, George E" sort="Theodoropoulos, George E" uniqKey="Theodoropoulos G" first="George E" last="Theodoropoulos">George E. Theodoropoulos</name><affiliation wicri:level="1"><nlm:affiliation>1st Propaideutic Surgical Department, Hippocration University Hospital, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Propaideutic Surgical Department, Hippocration University Hospital, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Tobias, Geoffrey S" sort="Tobias, Geoffrey S" uniqKey="Tobias G" first="Geoffrey S" last="Tobias">Geoffrey S. Tobias</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [3] Hellenic Health Foundation, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [3] Hellenic Health Foundation, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Vodicka, Pavel" sort="Vodicka, Pavel" uniqKey="Vodicka P" first="Pavel" last="Vodicka">Pavel Vodicka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="2"><nlm:affiliation>Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wu, Chen" sort="Wu, Chen" uniqKey="Wu C" first="Chen" last="Wu">Chen Wu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [2] New York University Cancer Institute, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [2] New York University Cancer Institute, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fuchs, Charles" sort="Fuchs, Charles" uniqKey="Fuchs C" first="Charles" last="Fuchs">Charles Fuchs</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. [3].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Stolzenberg Solomon, Rachael S" sort="Stolzenberg Solomon, Rachael S" uniqKey="Stolzenberg Solomon R" first="Rachael S" last="Stolzenberg-Solomon">Rachael S. Stolzenberg-Solomon</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Amundadottir, Laufey T" sort="Amundadottir, Laufey T" uniqKey="Amundadottir L" first="Laufey T" last="Amundadottir">Laufey T. Amundadottir</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1038/ng.3052</idno><idno type="RBID">pubmed:25086665</idno><idno type="pmid">25086665</idno><idno type="wicri:Area/PubMed/Corpus">000152</idno><idno type="wicri:Area/PubMed/Curation">000152</idno><idno type="wicri:Area/PubMed/Checkpoint">000173</idno><idno type="wicri:Area/Ncbi/Merge">000C31</idno><idno type="wicri:Area/Ncbi/Curation">000C31</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C31</idno><idno type="wicri:Area/Main/Merge">000381</idno><idno type="wicri:Area/Main/Curation">000392</idno><idno type="wicri:Area/Main/Exploration">000392</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.</title><author><name sortKey="Wolpin, Brian M" sort="Wolpin, Brian M" uniqKey="Wolpin B" first="Brian M" last="Wolpin">Brian M. Wolpin</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Rizzato, Cosmeri" sort="Rizzato, Cosmeri" uniqKey="Rizzato C" first="Cosmeri" last="Rizzato">Cosmeri Rizzato</name><affiliation wicri:level="3"><nlm:affiliation>1] Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2].</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. [3].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Petersen, Gloria M" sort="Petersen, Gloria M" uniqKey="Petersen G" first="Gloria M" last="Petersen">Gloria M. Petersen</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Arslan, Alan A" sort="Arslan, Alan A" uniqKey="Arslan A" first="Alan A" last="Arslan">Alan A. Arslan</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA. [2] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [3] New York University Cancer Institute, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA. [2] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [3] New York University Cancer Institute, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Beane Freeman, Laura" sort="Beane Freeman, Laura" uniqKey="Beane Freeman L" first="Laura" last="Beane-Freeman">Laura Beane-Freeman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M" last="Bracci">Paige M. Bracci</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Buring, Julie" sort="Buring, Julie" uniqKey="Buring J" first="Julie" last="Buring">Julie Buring</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="3"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:affiliation>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. [3] Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. [3] Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J" last="Goodman">Phyllis J. Goodman</name><affiliation wicri:level="2"><nlm:affiliation>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J" last="Jacobs">Eric J. Jacobs</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kamineni, Aruna" sort="Kamineni, Aruna" uniqKey="Kamineni A" first="Aruna" last="Kamineni">Aruna Kamineni</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Klein, Alison P" sort="Klein, Alison P" uniqKey="Klein A" first="Alison P" last="Klein">Alison P. Klein</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="2"><nlm:affiliation>The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Cancer Research Center of Hawaii (retired), Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Kulke, Matthew H" sort="Kulke, Matthew H" uniqKey="Kulke M" first="Matthew H" last="Kulke">Matthew H. Kulke</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Donghui" sort="Li, Donghui" uniqKey="Li D" first="Donghui" last="Li">Donghui Li</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Centre, Madrid</wicri:regionArea><wicri:noRegion>Madrid</wicri:noRegion></affiliation></author><author><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H" last="Olson">Sara H. Olson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D" last="Sesso">Howard D. Sesso</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="4"><nlm:affiliation>1] Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C" last="Abnet">Christian C. Abnet</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Austin, Melissa A" sort="Austin, Melissa A" uniqKey="Austin M" first="Melissa A" last="Austin">Melissa A. Austin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Barfield, Richard" sort="Barfield, Richard" uniqKey="Barfield R" first="Richard" last="Barfield">Richard Barfield</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Basso, Daniela" sort="Basso, Daniela" uniqKey="Basso D" first="Daniela" last="Basso">Daniela Basso</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital of Padova, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital of Padova, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="1"><nlm:affiliation>1] INSERM, Centre for Research in Epidemiology and Population Health (CESP), Nutrition, Hormones and Women's Health Team, Villejuif, France. [2] University Paris Sud, UMRS 1018, Villejuif, France. [3] Institut Gustave Roussy (IGR), Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM, Centre for Research in Epidemiology and Population Health (CESP), Nutrition, Hormones and Women's Health Team, Villejuif, France. [2] University Paris Sud, UMRS 1018, Villejuif, France. [3] Institut Gustave Roussy (IGR), Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Brotzman, Michelle" sort="Brotzman, Michelle" uniqKey="Brotzman M" first="Michelle" last="Brotzman">Michelle Brotzman</name><affiliation wicri:level="2"><nlm:affiliation>Westat, Rockville, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Westat, Rockville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W" last="Büchler">Markus W. Büchler</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation wicri:level="3"><nlm:affiliation>1] National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. [2] Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, the Netherlands. [3] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>1] National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. [2] Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, the Netherlands. [3] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden-Württemberg-Hessen, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, DKFZ, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Capurso, Gabriele" sort="Capurso, Gabriele" uniqKey="Capurso G" first="Gabriele" last="Capurso">Gabriele Capurso</name><affiliation wicri:level="3"><nlm:affiliation>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Chung, Charles" sort="Chung, Charles" uniqKey="Chung C" first="Charles" last="Chung">Charles Chung</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="4"><nlm:affiliation>1] Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. [2] Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. [2] Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Elena, Joanne" sort="Elena, Joanne" uniqKey="Elena J" first="Joanne" last="Elena">Joanne Elena</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Funel, Niccola" sort="Funel, Niccola" uniqKey="Funel N" first="Niccola" last="Funel">Niccola Funel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa</wicri:regionArea><wicri:noRegion>Pisa</wicri:noRegion></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A" last="Giese">Nathalia A. Giese</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Surgery, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Goggins, Michael" sort="Goggins, Michael" uniqKey="Goggins M" first="Michael" last="Goggins">Michael Goggins</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [3] Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Pathology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Medicine, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland, USA. [3] Department of Oncology, Sidney Kimmel Cancer Center and Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gorman, Megan J" sort="Gorman, Megan J" uniqKey="Gorman M" first="Megan J" last="Gorman">Megan J. Gorman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gross, Myron" sort="Gross, Myron" uniqKey="Gross M" first="Myron" last="Gross">Myron Gross</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:affiliation>Preventive Medicine, University of Southern California, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Preventive Medicine, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hassan, Manal" sort="Hassan, Manal" uniqKey="Hassan M" first="Manal" last="Hassan">Manal Hassan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation wicri:level="2"><nlm:affiliation>Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Prevention, University of Southern California, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Prevention, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A" last="Holly">Elizabeth A. Holly</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hu, Nan" sort="Hu, Nan" uniqKey="Hu N" first="Nan" last="Hu">Nan Hu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard School of Public Health, Boston, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard School of Public Health, Boston, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Innocenti, Federico" sort="Innocenti, Federico" uniqKey="Innocenti F" first="Federico" last="Innocenti">Federico Innocenti</name><affiliation wicri:level="2"><nlm:affiliation>The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of North Carolina Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, DKFZ, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><nlm:affiliation>School of Clinical Medicine, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Medicine, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Klein, Eric A" sort="Klein, Eric A" uniqKey="Klein E" first="Eric A" last="Klein">Eric A. Klein</name><affiliation wicri:level="2"><nlm:affiliation>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>1] Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [2] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [3] Department of Nutrition, National School of Public Health, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>1] Centre de Recerca en Epidemiologia Ambiental (CREAL), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [2] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [3] Department of Nutrition, National School of Public Health, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Kupcinskas, Juozas" sort="Kupcinskas, Juozas" uniqKey="Kupcinskas J" first="Juozas" last="Kupcinskas">Juozas Kupcinskas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Kurtz, Robert C" sort="Kurtz, Robert C" uniqKey="Kurtz R" first="Robert C" last="Kurtz">Robert C. Kurtz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T" last="Landi">Maria T. Landi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Landi, Stefano" sort="Landi, Stefano" uniqKey="Landi S" first="Stefano" last="Landi">Stefano Landi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Pisa, Pisa</wicri:regionArea><wicri:noRegion>Pisa</wicri:noRegion></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Mambrini, Andrea" sort="Mambrini, Andrea" uniqKey="Mambrini A" first="Andrea" last="Mambrini">Andrea Mambrini</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Department, ASL1 Massa Carrara, Massa Carrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Oncology Department, ASL1 Massa Carrara, Massa Carrara</wicri:regionArea><wicri:noRegion>Massa Carrara</wicri:noRegion></affiliation></author><author><name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:affiliation>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation wicri:level="3"><nlm:affiliation>Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L" last="Oberg">Ann L. Oberg</name><affiliation wicri:level="2"><nlm:affiliation>Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Owzar, Kouros" sort="Owzar, Kouros" uniqKey="Owzar K" first="Kouros" last="Owzar">Kouros Owzar</name><affiliation wicri:level="2"><nlm:affiliation>Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alliance Statistics and Data Center, Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V" last="Patel">Alpa V. Patel</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H M" last="Peeters">Petra H M. Peeters</name><affiliation wicri:level="3"><nlm:affiliation>1] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Pezzilli, Raffaele" sort="Pezzilli, Raffaele" uniqKey="Pezzilli R" first="Raffaele" last="Pezzilli">Raffaele Pezzilli</name><affiliation wicri:level="1"><nlm:affiliation>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Piepoli, Ada" sort="Piepoli, Ada" uniqKey="Piepoli A" first="Ada" last="Piepoli">Ada Piepoli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Scientific Institute and Regional General Hospital 'Casa Sollievo della Sofferenza', Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gastroenterology, Scientific Institute and Regional General Hospital 'Casa Sollievo della Sofferenza', Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Porta, Miquel" sort="Porta, Miquel" uniqKey="Porta M" first="Miquel" last="Porta">Miquel Porta</name><affiliation wicri:level="4"><nlm:affiliation>1] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [2] Department of Epidemiology, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. [3] CIBERESP, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1] Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Spain. [2] Department of Epidemiology, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. [3] CIBERESP, Madrid</wicri:regionArea><orgName type="university">Université autonome de Barcelone</orgName><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Real, Francisco X" sort="Real, Francisco X" uniqKey="Real F" first="Francisco X" last="Real">Francisco X. Real</name><affiliation wicri:level="4"><nlm:affiliation>1] Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain. [2] Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1] Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, Madrid, Spain. [2] Departament de Ciències i de la Salut, Universitat Pompeu Fabra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université Pompeu Fabra</orgName></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name><affiliation wicri:level="1"><nlm:affiliation>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T" last="Silverman">Debra T. Silverman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Soucek, Pavel" sort="Soucek, Pavel" uniqKey="Soucek P" first="Pavel" last="Soucek">Pavel Soucek</name><affiliation wicri:level="3"><nlm:affiliation>Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Toxicogenomics Unit, Center for Toxicology and Safety, National Institute of Public Health, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical and Perioperative Sciences, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Talar Wojnarowska, Renata" sort="Talar Wojnarowska, Renata" uniqKey="Talar Wojnarowska R" first="Renata" last="Talar-Wojnarowska">Renata Talar-Wojnarowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Digestive Tract Diseases, Medical University of Łodz, Łodz</wicri:regionArea><wicri:noRegion>Łodz</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R" last="Taylor">Philip R. Taylor</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Theodoropoulos, George E" sort="Theodoropoulos, George E" uniqKey="Theodoropoulos G" first="George E" last="Theodoropoulos">George E. Theodoropoulos</name><affiliation wicri:level="1"><nlm:affiliation>1st Propaideutic Surgical Department, Hippocration University Hospital, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Propaideutic Surgical Department, Hippocration University Hospital, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Tobias, Geoffrey S" sort="Tobias, Geoffrey S" uniqKey="Tobias G" first="Geoffrey S" last="Tobias">Geoffrey S. Tobias</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [3] Hellenic Health Foundation, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [3] Hellenic Health Foundation, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Vodicka, Pavel" sort="Vodicka, Pavel" uniqKey="Vodicka P" first="Pavel" last="Vodicka">Pavel Vodicka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="2"><nlm:affiliation>Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wu, Chen" sort="Wu, Chen" uniqKey="Wu C" first="Chen" last="Wu">Chen Wu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [2] New York University Cancer Institute, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [2] New York University Cancer Institute, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fuchs, Charles" sort="Fuchs, Charles" uniqKey="Fuchs C" first="Charles" last="Fuchs">Charles Fuchs</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. [3].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Stolzenberg Solomon, Rachael S" sort="Stolzenberg Solomon, Rachael S" uniqKey="Stolzenberg Solomon R" first="Rachael S" last="Stolzenberg-Solomon">Rachael S. Stolzenberg-Solomon</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Amundadottir, Laufey T" sort="Amundadottir, Laufey T" uniqKey="Amundadottir L" first="Laufey T" last="Amundadottir">Laufey T. Amundadottir</name><affiliation wicri:level="2"><nlm:affiliation>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="e-ISSN">1546-1718</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study (methods)</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pancreatic Neoplasms (genetics)</term><term>Polymorphism, Single Nucleotide (genetics)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term><term>Pancreatic Neoplasms</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Japon</li><li>Lituanie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Bade-Wurtemberg</li><li>Bohême centrale</li><li>Californie</li><li>Caroline du Nord</li><li>Catalogne</li><li>Connecticut</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Hawaï</li><li>Hovedstaden</li><li>Latium</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>Ohio</li><li>Ontario</li><li>Oxfordshire</li><li>Tennessee</li><li>Texas</li><li>Utrecht (province)</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Cambridge</li><li>Copenhague</li><li>Heidelberg</li><li>Londres</li><li>Lyon</li><li>Mannheim</li><li>Oxford</li><li>Prague</li><li>Rome</li><li>Tokyo</li><li>Toronto</li><li>Utrecht</li></settlement><orgName><li>Université Pompeu Fabra</li><li>Université autonome de Barcelone</li><li>Université d'Oxford</li><li>Université de Californie du Sud</li><li>Université de Cambridge</li><li>Université de Toronto</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Wolpin, Brian M" sort="Wolpin, Brian M" uniqKey="Wolpin B" first="Brian M" last="Wolpin">Brian M. Wolpin</name></region><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C" last="Abnet">Christian C. Abnet</name><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><name sortKey="Amundadottir, Laufey T" sort="Amundadottir, Laufey T" uniqKey="Amundadottir L" first="Laufey T" last="Amundadottir">Laufey T. Amundadottir</name><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><name sortKey="Arslan, Alan A" sort="Arslan, Alan A" uniqKey="Arslan A" first="Alan A" last="Arslan">Alan A. Arslan</name><name sortKey="Austin, Melissa A" sort="Austin, Melissa A" uniqKey="Austin M" first="Melissa A" last="Austin">Melissa A. Austin</name><name sortKey="Barfield, Richard" sort="Barfield, Richard" uniqKey="Barfield R" first="Richard" last="Barfield">Richard Barfield</name><name sortKey="Beane Freeman, Laura" sort="Beane Freeman, Laura" uniqKey="Beane Freeman L" first="Laura" last="Beane-Freeman">Laura Beane-Freeman</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M" last="Bracci">Paige M. Bracci</name><name sortKey="Brotzman, Michelle" sort="Brotzman, Michelle" uniqKey="Brotzman M" first="Michelle" last="Brotzman">Michelle Brotzman</name><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><name sortKey="Buring, Julie" sort="Buring, Julie" uniqKey="Buring J" first="Julie" last="Buring">Julie Buring</name><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><name sortKey="Chung, Charles" sort="Chung, Charles" uniqKey="Chung C" first="Charles" last="Chung">Charles Chung</name><name sortKey="Elena, Joanne" sort="Elena, Joanne" uniqKey="Elena J" first="Joanne" last="Elena">Joanne Elena</name><name sortKey="Fuchs, Charles" sort="Fuchs, Charles" uniqKey="Fuchs C" first="Charles" last="Fuchs">Charles Fuchs</name><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><name sortKey="Goggins, Michael" sort="Goggins, Michael" uniqKey="Goggins M" first="Michael" last="Goggins">Michael Goggins</name><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J" last="Goodman">Phyllis J. Goodman</name><name sortKey="Gorman, Megan J" sort="Gorman, Megan J" uniqKey="Gorman M" first="Megan J" last="Gorman">Megan J. Gorman</name><name sortKey="Gross, Myron" sort="Gross, Myron" uniqKey="Gross M" first="Myron" last="Gross">Myron Gross</name><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><name sortKey="Hassan, Manal" sort="Hassan, Manal" uniqKey="Hassan M" first="Manal" last="Hassan">Manal Hassan</name><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A" last="Holly">Elizabeth A. Holly</name><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name><name sortKey="Hu, Nan" sort="Hu, Nan" uniqKey="Hu N" first="Nan" last="Hu">Nan Hu</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><name sortKey="Innocenti, Federico" sort="Innocenti, Federico" uniqKey="Innocenti F" first="Federico" last="Innocenti">Federico Innocenti</name><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J" last="Jacobs">Eric J. Jacobs</name><name sortKey="Kamineni, Aruna" sort="Kamineni, Aruna" uniqKey="Kamineni A" first="Aruna" last="Kamineni">Aruna Kamineni</name><name sortKey="Klein, Alison P" sort="Klein, Alison P" uniqKey="Klein A" first="Alison P" last="Klein">Alison P. Klein</name><name sortKey="Klein, Eric A" sort="Klein, Eric A" uniqKey="Klein E" first="Eric A" last="Klein">Eric A. Klein</name><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kulke, Matthew H" sort="Kulke, Matthew H" uniqKey="Kulke M" first="Matthew H" last="Kulke">Matthew H. Kulke</name><name sortKey="Kurtz, Robert C" sort="Kurtz, Robert C" uniqKey="Kurtz R" first="Robert C" last="Kurtz">Robert C. Kurtz</name><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T" last="Landi">Maria T. Landi</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Li, Donghui" sort="Li, Donghui" uniqKey="Li D" first="Donghui" last="Li">Donghui Li</name><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L" last="Oberg">Ann L. Oberg</name><name sortKey="Olson, Sara H" sort="Olson, Sara H" uniqKey="Olson S" first="Sara H" last="Olson">Sara H. Olson</name><name sortKey="Owzar, Kouros" sort="Owzar, Kouros" uniqKey="Owzar K" first="Kouros" last="Owzar">Kouros Owzar</name><name sortKey="Patel, Alpa V" sort="Patel, Alpa V" uniqKey="Patel A" first="Alpa V" last="Patel">Alpa V. Patel</name><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><name sortKey="Petersen, Gloria M" sort="Petersen, Gloria M" uniqKey="Petersen G" first="Gloria M" last="Petersen">Gloria M. Petersen</name><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D" last="Sesso">Howard D. Sesso</name><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T" last="Silverman">Debra T. Silverman</name><name sortKey="Stolzenberg Solomon, Rachael S" sort="Stolzenberg Solomon, Rachael S" uniqKey="Stolzenberg Solomon R" first="Rachael S" last="Stolzenberg-Solomon">Rachael S. Stolzenberg-Solomon</name><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R" last="Taylor">Philip R. Taylor</name><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><name sortKey="Tobias, Geoffrey S" sort="Tobias, Geoffrey S" uniqKey="Tobias G" first="Geoffrey S" last="Tobias">Geoffrey S. Tobias</name><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><name sortKey="Wu, Chen" sort="Wu, Chen" uniqKey="Wu C" first="Chen" last="Wu">Chen Wu</name><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Rizzato, Cosmeri" sort="Rizzato, Cosmeri" uniqKey="Rizzato C" first="Cosmeri" last="Rizzato">Cosmeri Rizzato</name></region><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W" last="Büchler">Markus W. Büchler</name><name sortKey="Bugert, Peter" sort="Bugert, Peter" uniqKey="Bugert P" first="Peter" last="Bugert">Peter Bugert</name><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A" last="Giese">Nathalia A. Giese</name><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. 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Giles</name></noRegion><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name></country><country name="Italie"><noRegion><name sortKey="Basso, Daniela" sort="Basso, Daniela" uniqKey="Basso D" first="Daniela" last="Basso">Daniela Basso</name></noRegion><name sortKey="Capurso, Gabriele" sort="Capurso, Gabriele" uniqKey="Capurso G" first="Gabriele" last="Capurso">Gabriele Capurso</name><name sortKey="Funel, Niccola" sort="Funel, Niccola" uniqKey="Funel N" first="Niccola" last="Funel">Niccola Funel</name><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><name sortKey="Landi, Stefano" sort="Landi, Stefano" uniqKey="Landi S" first="Stefano" last="Landi">Stefano Landi</name><name sortKey="Mambrini, Andrea" sort="Mambrini, Andrea" uniqKey="Mambrini A" first="Andrea" last="Mambrini">Andrea Mambrini</name><name sortKey="Pezzilli, Raffaele" sort="Pezzilli, Raffaele" uniqKey="Pezzilli R" first="Raffaele" last="Pezzilli">Raffaele Pezzilli</name><name sortKey="Piepoli, Ada" sort="Piepoli, Ada" uniqKey="Piepoli A" first="Ada" last="Piepoli">Ada Piepoli</name><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name></country><country name="France"><noRegion><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name></noRegion><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name></noRegion><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H M" last="Peeters">Petra H M. Peeters</name><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name></country><country name="Grèce"><noRegion><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name></noRegion><name sortKey="Theodoropoulos, George E" sort="Theodoropoulos, George E" uniqKey="Theodoropoulos G" first="George E" last="Theodoropoulos">George E. Theodoropoulos</name><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name></country><country name="Lituanie"><noRegion><name sortKey="Kupcinskas, Juozas" sort="Kupcinskas, Juozas" uniqKey="Kupcinskas J" first="Juozas" last="Kupcinskas">Juozas Kupcinskas</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name></noRegion></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Soucek, Pavel" sort="Soucek, Pavel" uniqKey="Soucek P" first="Pavel" last="Soucek">Pavel Soucek</name></region><name sortKey="Vodicka, Pavel" sort="Vodicka, Pavel" uniqKey="Vodicka P" first="Pavel" last="Vodicka">Pavel Vodicka</name></country><country name="Suède"><noRegion><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Talar Wojnarowska, Renata" sort="Talar Wojnarowska, Renata" uniqKey="Talar Wojnarowska R" first="Renata" last="Talar-Wojnarowska">Renata Talar-Wojnarowska</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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